Objectives: Captopril is freely soluble in water and administered orally in two divided dose. In present investigation different polymers were used for sustained release of captopril from the formulated tablets. Experimental work: Sustained release matrix tablets were formulated using different hydrophilic hydroxypropyl methyl cellulose K 100 M, hydrophobic ethyl cellulose, and waxy carriers stearic acid and cetyl alcohol. These materials were used in different ratios with the active ingredient generally 1:1, 1:2, 1:3 and 1:4 ratio of drug: matrix material. Tableting was done by direct compression, and hot melts granulation. Results and discussion: Dissolution data showed that hydrophilic polymer HPMC K100 M containing tablet batch H3 and waxy polymer stearic acid containing tablet batch S4 provided sustained release of drug for 12hrs. Dissolution of marketed product captopril releases the drug within 6hrs. The release was found to follow zero order in E1, E2, E4, S4, C1 batches while other batches follow higuchi model. Conclusion: The developed tablet formulation with hydroxypropyl methyl cellulose at 1:3 (Batch H3) and Stearic acid at 1:4 (Batch S4) were able to provide sustained release profile for prolong period than marketed formulation.
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